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. 2019 Sep 7;8(11):1659095. doi: 10.1080/2162402X.2019.1659095

Figure 5.

Figure 5.

Analysis of cytokine release from redirected UniCAR T cells. Genetically engineered T cells (vector control, UniCAR Stop or UniCAR 28/ζ) were cultivated with or without PC3 cells (E:T = 5:1), either in the presence or in the absence of scFv-based αPSMA scFv-TM or PSMA PLT-TM. Data show concentrations of selected cytokines after 24 h and are reported as mean ± SD for four independent donors. (***p < .0002, **p < .002 with respect to UniCAR 28/ζ + tumor cells w/o TM; 2way ANOVA with Tukey’s multiple comparisons test).