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. 2019 Jul 17;8(11):e1641387. doi: 10.1080/2162402X.2019.1641387

Figure 1.

Figure 1.

Malignant CTCL cells are less sensitive to alpha-toxin than non-malignant CD4+ T cells. Cells were exposed to alpha-toxin before LDH release was measured in the culture supernatant and/or viability was assessed by flow cytometry. (a,b) Malignant CTCL patient derived cell lines and the non-malignant CTCL cell lines MySi and MyLa1850 (n = 3–5). (c,d) Purified primary CD4+ T cells from healthy donors and the malignant CTCL cell line, MyLa2059 (n = 2–4). (e,f) ADAM10 surface expression and survival of MyLa1850 after alpha-toxin exposure following GI254023X treatment (n = 3). (g,h) Surface expression of ADAM10 of siRNA transfected CD4+ T cells from healthy donors and survival after four days of toxin exposure (n = 2). Error bars display mean ± standard error of mean.