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. 2019 Oct 9;36(21):2977–2990. doi: 10.1089/neu.2018.6332

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© Krisztián Pajer et al., 2019; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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FIG. 5. — Expression of the various factors produced by the intraspinally grafted NE-GFP-4C stem cells and host spinal cord tissue one week after grafting. (A–D): The graft and the host tissues express glial cell derived neurotrophic factor (GDNF), interleukin (IL-)6, IL-10, and macrophage inflammatory protein (MIP)-1a. A′–D′ show the strong expression pattern of these factors within the graft (boxed areas taken from the graft region). In contrast, A″–D″ show the interface region between the graft (g) and the host (h) tissues with varying extent of expression intensity in the host (boxed areas taken from the graft-host interface). (E–H) None of these factors was found to be expressed in the spinal cords of control animals (medium-1w-isp). (I) Quantification of all four factors revealed an increased level of GDNF, IL6, IL-10, and MIP-1a immunoreactivity in intraspinally grafted group (NE4C-1w-isp) compared with controls (medium-1w-isp). Dashed line indicates the graft-host border. Data are expressed as mean ± standard error of the mean. *, significant difference between NE4C-1w-isp group with the control group (medium-1w-isp). Scale bars: A–H: 500 μm, A′–D′, A″–D″: 100 μm. Color image is available online.