Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Oct 9;36(21):2977–2990. doi: 10.1089/neu.2018.6332

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Krisztián Pajer et al., 2019; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

PMC Copyright notice

FIG. 6. — Functional blocking of the factors produced by the stem cells with neutralizing antibodies abolishes the motor recovery in grafted animals. (A): Open field locomotor test (Basso, Beattie, Bresnahan) shows that grafted animals (NE4C-isp-blocking) treated with neutralizing antibodies against the four secretome factors produce as little recovery as control rats (medium-1w-isp). Animals treated with isospecific immune globulin G (IgGs) (NE4C-1w-isp-isospecific) showed considerable improvement. The non-significant difference between NE4C-1w-isp and NE4C-1w-isp-isospecific groups is likely because of the effect of the implanted osmotic pump and tube. (B–D): Grafted animals treated with neutralizing antibodies also displayed surviving stem cell-derived astroglial cells (B, B′), neurons (C,C′), and oligodendrocytes in close relationship with NF-200 positive axons (D,D′). The presence of stem cell-derived cells may be responsible for the non-significant difference between NE4C-isp-blocking and medium-1w-isp groups. Data are expressed as mean ± standard error of the mean. *, significant difference between the intraspinally grafted animals with the control ones. B,C: 500 μm, B′,C′: 100 μm, D,D′: 50 μm. Color image is available online.