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. 2019 May 28;127(5):057011. doi: 10.1289/EHP3849

Figure 1.

Figure 1A is a Manhattan plot plotting negative log sub 10 (y-axis), ranging between 0 and 12, across chromosome (x-axis), ranging between 1 and 21. Figure 1B is a Volcano plot plotting negative log sub 10 (y-axis), ranging between 0 and 12, across log sub 2 HEALS Urinary Arsenic values, ranging between negative 0.02 and 0.02 micrograms per gram beta value. The relation to island key is as follows: island, non-CpG island, shelf, and shore.

Genome-wide associations between urinary arsenic concentration and CpG site–specific methylation in the Health Effects of Arsenic Longitudinal Study (HEALS). Using the EPIC (850K) array, the association between log2-transformed urinary arsenic (creatinine adjusted) and methylation was evaluated at 771,192 CpG sites across 396 individuals from HEALS. (A) Manhattan plot of the chromosomal location and p-value for each CpG–arsenic association. (B) Volcano plot presenting association estimate and p-value for each CpG–arsenic association. Colors correspond to CpG relationship to island. In (A) and (B), solid and dashed lines designate the Bonferroni threshold (p=6.5×10−8) and false discovery rate (FDR) 0.05 threshold (p=2.0×10−6), respectively.