Table 1. Lack of association between pre-challenge attributes of vaccine-induced immune responses in Groups 1 and 2 and acquisition of SIV infection1.
| Immunological variable | Hazard ratio (95% confidence interval) | P-value |
|---|---|---|
| Total breadth of SIV-specific CD8+ T-cell responses2 | 0.996 (0.457, 2.169) | 0.992 |
| Total magnitude of SIV-specific CD8+ T-cell responses3 | 1.061 (0.553, 2.038) | 0.858 |
| Serum midpoint titers of gp140-binding IgG Abs4 | 1.785 (0.763, 4.178) | 0.182 |
| Serum midpoint titers of gp120-binding IgG Abs4 | 1.451 (0.687, 3.064) | 0.329 |
| Serum titers of anti-SIVmac316 nAbs5 | 1.484 (0.765, 2.879) | 0.243 |
| ADCC activity against SIVmac239-infected cells6 | 0.799 (0.395, 1.617) | 0.533 |
| Rectal levels of gp140-binding IgG Abs7 | 0.855 (0.393, 1.862) | 0.693 |
1 To appropriately account for censoring (five animals in Group 1 and three in Group 2 did not acquire SIV infection), the Cox proportional hazard model was used for this analysis. As the scale of immunological responses varies, the values are standardized.
2 Based on the data shown in Fig 6C.
3 Based on the data shown in Fig 6D.
4 Based on the data shown in Fig 7E and 7F.
5 Based on the data shown in Fig 8A.
6 Based on the data shown in Fig 8B.
7 Based on the data shown in S8 Fig.