Table 2. Lack of association between pre-challenge attributes of vaccine-induced immune responses in Groups 1 and 2 and either peak or setpoint VLs¹.

Peak VLs	Immunological variable	Correlation coefficient	P-value
	Total breadth of SIV-specific CD8+ T-cell responses2	–0.301	0.468
	Total magnitude of SIV-specific CD8+ T-cell responses3	–0.381	0.360
	Serum midpoint titers of gp140-binding IgG Abs4	–0.262	0.536
	Serum midpoint titers of gp120-binding IgG Abs4	–0.238	0.582
	Serum titers of anti-SIVmac316 nAbs5	0.000	1.000
	ADCC activity against SIVmac239-infected cells6	0.071	0.882
	Rectal levels of gp140-binding IgG Abs7	–0.036	0.933
Setpoint VLs	Immunological variable	Correlation coefficient	P-value
	Total breadth of SIV-specific CD8+ T-cell responses2	–0.012	0.977
	Total magnitude of SIV-specific CD8+ T-cell responses3	–0.310	0.462
	Serum midpoint titers of gp140-binding IgG Abs4	–0.500	0.216
	Serum midpoint titers of gp120-binding IgG Abs4	–0.476	0.243
	Serum titers of anti-SIVmac316 nAbs5	0.167	0.703
	ADCC activity against SIVmac239-infected cells6	–0.190	0.665
	Rectal levels of gp140-binding IgG Abs7	–0.395	0.333

¹ This analysis included only the SIV-infected vaccinees in Group 1 (n = 3) and Group 2 (n = 5). The Spearman rank correlation was used to search for associations between the aforementioned immunological variables and plasma viral loads.

² Based on the data shown in Fig 6C.

³ Based on the data shown in Fig 6D.

⁴ Based on the data shown in Fig 7E and 7F.

⁵ Based on the data shown in Fig 8A.

⁶ Based on the data shown in Fig 8B.

⁷ Based on the data shown in S8 Fig.