Table 4.

Enrichment analysis for significantly overrepresented classes of the 60 metabolites in the modules that showed significant changes before, during, and after the Olympics in 26 nonsmoking adults.

Super pathways and pathways	p-Value	Adjusted p-Value	Metabolites (n)		Ratio (%)
			Module identified	In the pathway annotation
Lipid super pathway
Eicosanoid pathway	0.01	0.03	2	2	100%
Long-chain fatty acid pathway	$<0.01$	$<0.01$	12	17	71%
Polyunsaturated fatty acid (n3 and n6) pathway	$<0.01$	$<0.01$	9	14	64%
Medium-chain fatty acid pathway	0.01	0.02	4	8	50%
Fatty acid metabolism (acyl carnitine) pathway	$<0.01$	$<0.01$	6	12	50%
Nucleotide super pathway
Purine metabolism, (hypo)xanthine/inosine–containing pathway	0.03	0.05	3	6	50%
Peptide super pathway
Dipeptide pathway	$<0.01$	$<0.01$	24	61	39%

Note: Module analysis identified 69 metabolites that mapped to Metabolon classes, only classes with significant results (adjusted $p<0.05$) and more than one metabolite are shown. p-Values are calculated using Fisher’s exact test and adjusted with a Benjamini-Hochberg correction.