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. 2019 May 29;5(6):e458. doi: 10.1097/TXD.0000000000000898

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Copyright © 2019 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIGURE 4. — AAT treatment attenuates the recipients’ spleen T-cell proliferation in vitro. A one-way mixed lymphocyte reaction (MLR) was performed with the donor (Lewis) rat spleen (A) or lung (B) cells as stimulator cells. Lymphocytes isolated from recipients (SD) in both the control and AAT-treated groups were used as responder cells. Lymphocyte proliferation of cells from recipients treated with AAT was significantly inhibited in comparison to lymphocytes obtained from control animals. This level of proliferation was not significantly different from that observed with the use of responder lymphocytes from naïve (nontransplanted) SD rats. This result was irrespective of the use of either Lewis spleen (A) or the lung (B) as the stimulator cell. Data represent mean + SEM, n = 3 for each group; **P < 0.01 vs control. AAT, alpha-1 antitrypsin; SD, Sprague-Dawley; SEM, standard error of the mean.