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. 2019 Sep 16;18(21):2972–2985. doi: 10.1080/15384101.2019.1664225

Figure 8.

Figure 8.

FAM83A-AS1 affects cell migration and invasion through the miR-150-5p/MMP14 axis.

(a) Protein expression of MMP14 was determined in A549 and H1299 cells by western blot assay after transfection with negative control (NC) or siMMP14 or cotransfection with the FAM83A-AS1 plasmid and siMMP14. (b) Protein expression of MMP14 was determined in two LUAD cells by western blot assay after transfection with miR-NC, miR-150-5p mimic, or the FAM83A-AS1 plasmid or cotransfection with the FAM83A-AS1 plasmid and miR-150-5p mimic. (c) Spearman’s correlation analysis indicated the relationship between FAM83A-AS1 and miR-150-5p expression in LUAD tissues based on TCGA datasets. (d-e) Transwell assays were used to estimate cell migration and invasion abilities after transfection with NC, siMMP14, or the FAM83A-AS1 plasmid or cotransfection with the FAM83A-AS1 plasmid and siMMP14 in A549 and H1299 cells.