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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Chem Biol Drug Des. 2019 Jul 21;94(4):1711–1720. doi: 10.1111/cbdd.13564

Figure 2.

Figure 2

Transactivation of NR4A2 by substituted quinolines. Chloroquine and amodiaquine (A) were used in the transactivation assays. Panc1 and Panc28 cells were cotransfected with UAS-luciferase reporter constructs and GAL4-NR4A2 expression constructs followed by treatment with 200 μM CQ or 100 μM AQ (B). Panc1 (C) and Panc28 (D) cells were transfected with only UAS-luciferase plasmid and cells were treated with 7.5 and 15 μM bis-indole analogs, 200 μM CQ or 100 μM AQ. Luciferase activity fold induction was determined as described in the Materials and Methods. Results are expressed as mean ± SD for at least three independent determinations for each treatment. *, P < 0.01, treatment vs. solvent control (DMSO).