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Induction and termination of persistent firing in hepta-TRPC knockout mice. (a) An example of a neurons that showed voltage-dependent persistent firing in response a brief stimulus (0.2 s, +0.4 nA). The arrowhead indicates d.c. shift. (b) Persistent firing termination by prolonged hyperpolarizing current pulse (6 s, −0.6 nA). All recordings were performed in the presence of CCh, CNQX, APV and picrotoxin.
