Figure 6.

Activtiy dependent modulation of graded persistent firing in hepta-TRPC knockout mice. (a) Specimen trace showing that repetitive depolarizing current step gives initially increases of stable discharge rate followed, however, by its discrete decreases and full termination. The lower diagram correspond to the peristimulus histograms (bin width 700 ms). (b) Repetitive stimulation in same neuron after adding atropine. Recording was performed in the presence of CCh, CNQX, APV and picrotoxin.