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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: J Affect Disord. 2019 Aug 19;259:201–209. doi: 10.1016/j.jad.2019.08.055

Table 2.

Regression results from models with corrected significant SNPs x PTSD symptom severity interaction terms predicting cortical thickness

Variable LH lateral orbitofrontal thick LH superior frontal thick
β Std
Error		 T
value		 P
value		 Corrected
P 		β Std
Error		 T
value		 P
value		 Corrected
P
1. Covariates
Intercept 2.79 0.07 40.51 1.37 × 10−112 N/A 2.94 0.06 47.02 4.79 × 10−127 N/A
Age −6.54 × 10−3 <0.001 −5.70 3.39 × 10−8 N/A −7.27 × 10−3 <0.001 −6.97 2.83 × 10−11 N/A
Sex −2.34 × 10−2 0.04 −0.55 0.58 N/A −1.87 × 10−2 0.04 −0.48 0.63 N/A
PC1 −0.13 0.17 −0.72 0.47 N/A −0.18 0.16 −1.14 0.25 N/A
PC2 −0.23 0.18 −1.25 0.21 N/A −0.12 0.16 −0.73 0.47 N/A
PC3 0.13 0.17 0.76 0.45 N/A 9.17 × 10−2 0.16 0.58 0.56 N/A
Scanner flag 4.07 × 10−2 0.04 1.14 0.26 N/A 3.19 × 10−2 0.03 0.99 0.33 N/A
CAPS −1.54 × 10−4 <0.001 −0.49 0.62 N/A 1.48 × 104 <0.001 −0.52 0.60 N/A
2. SNP
rs9610608, G −1.11 × 10−2 0.02 −0.55 0.58 1.00 −1.84 × 10−2 0.02 −1.01 0.31 1.00
rs62237483, C −1.06 × 10−2 0.02 −0.54 0.59 1.00 −1.83 × 10−2 0.02 −1.03 0.30 1.00
rs9610645, A −8.06 × 10−3 0.02 −0.41 0.68 1.00 −1.61 × 10−2 0.02 −0.90 0.37 1.00
rs62234965, G −1.06 × 10−2 0.02 −0.54 0.59 1.00 −1.83 × 10−2 0.02 −1.03 0.30 1.00
rs199725385, C −1.06 × 10−2 0.02 −0.54 0.59 1.00 −1.83 × 10−2 0.02 −1.03 0.30 1.00
rs9610690, A −1.06 × 10−2 0.02 −0.54 0.59 1.00 −1.83 × 10−2 0.02 −1.03 0.30 1.00
3. Interaction
rs9610608, G −3.41 × 10−3 <0.001 −4.55 8.33 × 10−6 0.007* −2.77 × 10−3 <0.001 −4.04 7.21 × 10−5 0.048*
rs62237483, C −3.14 × 10−3 <0.001 −4.34 2.08 × 10−5 0.017* −2.56 × 10−3 <0.001 −3.87 1.40 × 10−4 0.085
rs9610645, A −3.12 × 10−3 <0.001 −4.30 2.46 × 10−5 0.019* −2.54 × 10−3 <0.001 −3.83 1.63 × 10−4 0.096
rs62234965, G −3.14 × 10−3 <0.001 −4.34 2.08 × 10−5 0.017* −2.56 × 10−3 <0.001 −3.87 1.40 × 10−4 0.085
rs199725385, C −3.14 × 10−3 <0.001 −4.34 2.08 × 10−5 0.017* −2.56 × 10−3 <0.001 −3.87 1.40 × 10−4 0.085
rs9610690, A −3.14 × 10−3 <0.001 −4.34 2.08 × 10−5 0.017* −2.56 × 10−3 <0.001 −3.87 1.40 × 10−4 0.085
Variable RH lateral orbitofrontal thick RH superior frontal thick
β Std
Error		 T
value		 P
value		 Corrected
P 		β Std
Error		 T
value		 P
value		 Corrected
P
1. Covariates
Intercept 2.55 0.07 38.55 6.62 × 10−108 N/A 2.81 0.06 47.88 7.61 × 10−129 N/A
Age −6.29 × 10−3 <0.002 −5.71 3.12 × 10−8 N/A −6.51 × 10−3 <0.001 −6.66 1.69 × 10−10 N/A
Sex 4.32 × 10−2 0.04 1.06 0.29 N/A −6.29 × 10−4 0.04 −0.02 0.99 N/A
PC1 0.28 0.17 1.65 0.10 N/A −3.13 × 10−2 0.15 −0.21 0.83 N/A
PC2 −9.54 × 10−2 0.17 −0.55 0.58 N/A −8.76 × 10−2 0.15 −0.57 0.57 N/A
PC3 0.17 0.17 1.04 0.30 N/A 0.33 0.15 2.21 0.03 N/A
Scanner flag 7.06 × 10−2 0.03 2.06 0.04 N/A 4.89 × 10−2 0.03 1.61 0.11 N/A
CAPS −2.76 × 10−4 <0.001 −0.92 0.36 N/A −2.21 × 104 <0.001 −0.83 0.41 N/A
2. SNP
rs9610608, G −1.52 × 10−2 0.02 −0.79 0.43 1.00 −2.40 × 10−2 0.02 −1.41 0.16 1.00
rs62237483, C −1.65 × 10−2 0.02 −0.88 0.38 1.00 −2.27 × 10−2 0.02 −1.36 0.17 1.00
rs9610645, A −1.77 × 10−2 0.02 −0.93 0.35 1.00 −2.37 × 10−2 0.02 −1.41 0.16 1.00
rs62234965, G −1.65 × 10−2 0.02 −0.88 0.38 1.00 −2.27 × 10−2 0.02 −1.36 0.17 1.00
rs199725385, C −1.65 × 10−2 0.02 −0.88 0.38 1.00 −2.27 × 10−2 0.02 −1.36 0.17 1.00
rs9610690, A −1.65 × 10−2 0.02 −0.88 0.38 1.00 −2.27 × 10−2 0.02 −1.36 0.17 1.00
3. Interaction
rs9610608, G −3.44 × 10−3 <0.001 −4.80 2.68 × 10−6 0.003* −2.83 × 10−3 <0.001 −4.44 1.37 × 10−5 0.01*
rs62237483, C −3.25 × 10−3 <0.001 −4.70 4.27 × 10−6 0.004* −2.56 × 10−3 <0.001 −4.15 4.50 × 10−5 0.03*
rs9610645, A −3.29 × 10−3 <0.001 −4.74 3.59 × 10−6 0.004* −2.59 × 10−3 <0.001 −4.19 3.80 × 10−5 0.03*
rs62234965, G −3.25 × 10−3 <0.001 −4.70 4.27 × 10−6 0.004* −2.56 × 10−3 <0.001 −4.15 4.50 × 10−5 0.03*
rs199725385, C −3.25 × 10−3 <0.001 −4.70 4.27 × 10−6 0.004* −2.56 × 10−3 <0.001 −4.15 4.50 × 10−5 0.03*
rs9610690, A −3.25 × 10−3 <0.001 −4.70 4.27 × 10−6 0.004* −2.56 × 10−3 <0.001 −4.15 4.50 × 10−5 0.03*
Variable RH pars triangularis
β Std
Error		 T
value		 P
value		 Corrected
P
1. Covariates
Intercept 2.53 0.06 39.22 1.58 × 10−109 N/A
Age −7.10 × 10−3 0.001 −6.58 2.62 × 10−10 N/A
Sex 3.64 × 10−2 0.04 0.91 0.36 N/A
PC1 1.50 × 10−2 0.16 0.09 0.93 N/A
PC2 −4.61 × 10−3 0.17 −0.03 0.98 N/A
PC3 0.25 0.16 1.50 0.13 N/A
Scanner flag 6.15 × 10−2 0.03 1.84 0.07 N/A
CAPS −2.98 × 10−4 <0.001 −1.02 0.31 N/A
2. SNP
rs9610608, G −2.05 × 10−2 0.02 −1.09 0.28 1.00
rs62237483, C −1.90 × 10−2 0.02 −1.04 0.30 1.00
rs9610645, A −1.87 × 10−2 0.02 −1.02 0.31 1.00
rs62234965, G −1.90 × 10−2 0.02 −1.04 0.30 1.00
rs199725385, C −1.90 × 10−2 0.02 −1.04 0.30 1.00
rs9610690, A −1.90 × 10−2 0.02 −1.04 0.30 1.00
3. Interaction
rs9610608, G −2.89 × 10−3 <0.001 −4.10 5.62 × 10−5 0.04*
rs62237483, C −2.62 × 10−3 <0.001 −3.83 1.60 × 10−4 0.095
rs9610645, A −2.67 × 10−3 <0.001 −3.91 1.17 × 10−4 0.073
rs62234965, G −2.62 × 10−3 <0.001 −3.83 1.60 × 10−4 0.095
rs199725385, C −2.62 × 10−3 <0.001 −3.83 1.60 × 10−4 0.095
rs9610690, A −2.62 × 10−3 <0.001 −3.83 1.60 × 10−4 0.095

Note: Corrected P indicates p-value after correction for multiple comparison using Monte-Carlo null simulation with 10,000 replicates. β estimates are unstandardized. Only the results from models in which the interaction term was significantly associated with cortical thickness after correction for multiple testing are shown. The minor allele is shown next to the SNP. CAPS=Clinician-Administered PTSD Scale; LH=left hemisphere; RH=right hemisphere; SNP=single nucleotide polymorphism; std=standard; thick=thickness