TABLE 4.
Clinicopathologic factors associated with overall survival for entire cohort
| Variable | Univariable Cox regression | Multivariable Cox regression | ||
|---|---|---|---|---|
| HR (95% CI) |
P value |
HR (95% CI) |
P value |
|
| Age at diagnosis, y | ||||
| ≤60 | Reference | Reference | ||
| >60 | 3.07 (1.92–4.90) | <.01 | 1.91 (1.17–3.12) |
<.01 |
| Sex | ||||
| Male | Reference | - | ||
| Female | 1.13 (0.73–1.76) | .59 | - | |
| Race | ||||
| White | Reference | - | ||
| Non - White | 2.06 (1.23–3.44) | .06 | - | |
| Charlson-Deyo score | ||||
| 0 | Reference | - | ||
| 1 | 1.25 (0.72–2.19) | .43 | - | |
| 2+ | 2.51 (1.14–5.51) | .02 | - | |
| Tumor differentiation | ||||
| Well | Reference | Reference | ||
| Moderately | 1.48 (0.48–4.58) | .05 | 1.32 (0.42–4.14) |
.63 |
| Poorly/ | 9.26 | <.01 | 3.65 | <.01 |
| undifferentiated | (4.96–17.30) | (1.87–7.11) | ||
| Not determined | 0.55 (0.22–1.39) | .21 | 0.51 (0.20–1.31) |
.16 |
| Margin status | ||||
| Negative | Reference | - | ||
| Positive | 2.75 (1.63–4.63) | <.01 | - | |
| PReSS risk group | ||||
| Group 0 | Reference | Reference | ||
| Group 1 | 1.97 (0.40–9.76) | 0.41 | 1.35 (0.27–6.74) |
.72 |
| Group 2 | 11.70 (3.33–41.06) |
<.01 | 5.47 (1.50–19.98) |
.01 |
| Group 3 | 25.49 (7.99–81.31) |
<.01 | 8.61 (2.53–29.22) |
<.01 |
Note: Number of observations in the original data set = 383. Number of observations used = 320. Bold indicates statistical significance. Backward selection with an α level of removal of .05 was used. The following variables were removed from the model: sex, Charlson‐Deyo score, margin status.
Abbreviaitons: CI, confidence interval; HR, hazard ratio; PReSS, Pre-operative Rectal Stratification Score.