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. Author manuscript; available in PMC: 2019 Nov 15.
Published in final edited form as: Cell. 2018 Oct 18;175(5):1272–1288.e20. doi: 10.1016/j.cell.2018.09.032

Figure 2. Cross-Linking Mass Spectrometry of SWI/SNF Complexes Reveals Conserved Connectivity of Interacting Modules.

Figure 2.

(A) Matrix heatmap of the total crosslinks identified in combined HA-SS18 and HA-DPF2 BAF complex cross-linking mass spectrometry datasets. Individual subunits are divided into domains and ordered according to modules in (B). See also Figures S2B, S2J, and S2K.

(B-D) Louvain modularity analysis performed on (B) mammalian cBAF complex cross-linking mass spectrometry datasets, (C) D. melanogaster D4 and BAP60 cross-linking mass spectrometry datasets, and (D) S. cerevisiae cross-linking mass spectrometry datasets (from Sen et al., 2017).

(E) Correlations between mammalian and Drosophila BAF or BAP subunit domain and region interactions from cross-linking mass spectrometry datasets. See also Figures S2B and S2J.

(F) Correlations between mammalian and yeast SWI/SNF subunit domain and region interactions from cross-linking mass spectrometry datasets. See also Figures S2B and S2K.

See also Figure S2.