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. 2019 Oct 14;9:14736. doi: 10.1038/s41598-019-51094-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The enriched canonical pathways found in the IPA analysis²⁷ (P < 0.05, FDR <0.1). The pathways are shown on the x-axis and the –Log Benjamini-Hochberg adjusted p values are displayed on the y-axis. The threshold is set to 1 which equals a Benjamini-Hochberg adjusted p value of 0.1. The orange line representing the ratio corresponds to the ratio of the number of differentially expressed genes that map to the pathway divided by the total number of genes that map to the same pathway. Pathways with a positive z-score are predicted by IPA to have increased activity and pathways with a negative z-score are predicted to have decreased activity.