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ADAM-17 expression and clinical outcome of sorafenib treatment
| ADAM-17 mRNA expression | P | ||
|---|---|---|---|
| High (n = 26) | Low (n = 26) | ||
| TTP | 9.0 | 12.0 | 0.024 |
| 7.3–10.7 (M) | 9.4–12.1 (M) | ||
| OS | 10.0 | 13.0 | 0.033 |
| 6.6–11.4 (M) | 10.8–14.6 (M) | ||
| Overall response rate (PR) | 0 (0%) | 4 (15.38%) | |
| Disease control rate (PR + SD) | 4 (15.38%) | 9 (34.61%) | |
CR complete remission, M months, OS overall survival, PR partial remission, SD stable of disease, TTP time to progress
