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. 2019 Oct 8;10:741. doi: 10.3389/fpsyt.2019.00741

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Copyright © 2019 Wu, Ou, Liu, Chen, Li, Zhao, Guo and Fan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SVR analysis indicates that decreased levels of fALFF in the right putamen after 1 week of olanzapine treatment may predict improvement in positive symptoms after 8 weeks of olanzapine treatment. Left: 3D visualization of SVR results with the best parameters (best c = 22.6274, g = 0.015625) using the grid search method. Right: A positive correlation between predicted and actual reduction rates of individual level PANSS positive symptoms subscale scores after 8 weeks of treatment (r = 0.431, p = 0.014). The predicted reduction rates were calculated based on decreased levels of fALFF in the right putamen after 1 week of olanzapine treatment using the LIBSVM software. SVR, support vector regression; MSE, mean square error; fALFF, fractional amplitude of low frequency fluctuation; PANSS, the Positive and Negative Syndrome Scale.