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. 2019 Sep 2;38(20):e101430. doi: 10.15252/embj.2018101430

Figure 8. Biological model of the current study.

Figure 8

Schematic model of the current study. In an unperturbed G2 phase, cyclin F promotes the degradation of the transcription repressors E2F7/8, which leads to enhanced expression of their target genes, such as RAD51, CHEK1, and MSH2 (left). Therefore, cyclin F‐dependent degradation of E2F7/8 sustains the expression of DNA repair genes before mitosis. Inactivation of cyclin F results in stabilization of E2F7 and E2F8 in G2 phase (right). Active E2F7/8 at this stage repress the expression of DNA repair genes, leading to accumulation of DNA damage and delayed cell cycle progression.