Table 1.
Top hits of the viability screen comparing HeLa to CCNF K/O using the KCGS
| Compound name | Δ z‐score | Target | |
|---|---|---|---|
| 100 nM | |||
| More sensitive | |||
| C10 | VE‐822 | −0.61484 | ATR |
| B17 | CCT251545 | −0.56548 | CDK8, CDK19 |
| I03 | GSK2336394 | −0.4252 | PIK3CB |
| Less sensitive | |||
| A20 | GW784752X | 1.016439 | GSK3b |
| A21 | GW580509X | 1.052113 | VEGFR2 |
| E22 | GW296115X | 1.443446 | PDGFR |
| 1 μM | |||
| More sensitive | |||
| B08 | CCT244747 | −2.88143 | CHK1 |
| E16 | BI00614644 | −0.56505 | MAPKAPK2, MAPKAPK5, PIM3, PHKG2 |
| I05 | SB‐725317 | −0.55738 | CDK2/cyclinA, LTK |
| Less sensitive | |||
| C11 | SB‐590885 | 1.036447 | B‐raf |
| B03 | JNK‐IN‐7 | 1.164645 | JNK |
| E22 | GW296115X | 1.180556 | PDGFRB |
| D15 | GW814408X | 1.364238 | GSK3b |
| H16 | GSK1070916 | 1.572064 | Aurora kinase |
| D12 | CA93.0 | 2.072805 | GAK1 |
| 10 μM | |||
| More sensitive | |||
| H19 | GW807982X | −1.06323 | GSK3b |
| I20 | TPKI‐39 | −0.86181 | CIT, KIT, PDGFRB, CSF1R, PDGFRA, DDR1, FLT1, TIE2 |
| C13 | GSK1838705 | −0.73301 | IGF1R, IR |
| Less sensitive | |||
| G14 | PFE‐PKIS 3 | 0.838916 | TNK2, TYRO3, YES, FGFR1,2,&3 |
| H11 | CCT241533 | 0.859239 | CHK2 |
| G09 | GW440135 | 0.866643 | KIT, NEK7, MEK5, PDGFRB, VEGFR2, NEK9, PDGFRA, FLT4 |