Table 1. Binding Affinities of Selected Compounds to Lyn SH3 and Fyn SH3.
|
Kd (μM) |
||
|---|---|---|
| Compound | Lyn SH3 | Fyn SH3 |
| 3 | 37 ± 22 | 127 ± 75 |
| 4a | 0.066 ± 0.023 | --- |
| 4b | 0.027 ± 0.012 | 9.6 ± 1.1 |
| 4c | 0.140 ± 0.032 | 12.0 ± 1.8 |
| 12c | 55 ± 17 | 7.2 ± 1.1 |
| Rh2(OAc)4 | >10 | --- |
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