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. 2019 Sep 10;10(10):1400–1406. doi: 10.1021/acsmedchemlett.9b00161

Table 1. In Vitro Cytotoxicity Activity of CuB and Prodrugs.

  IC50a (μM)
  
Compound MCF-7 Verob MCF-7+DIC CIc
CuB 12.0 ± 0.4 0.04 ± 0.02 9.72 ± 1.08  
1 18.1 ± 0.4 12.4 ± 0.5 >100 310
2 15.4 ± 0.2 1.87 ± 0.24 >100 46.8
3 16.6 ± 0.9 0.07 ± 0.02 >100 1.75
TAM 22.6 ± 0.3      
Ellipticine   4.06 ± 0.58    
a

Each value was reproduced in three experiments.

b

African green monkey kidney.

c

Cytotoxicity index, IC50 of prodrug in Vero compared with IC50 of CuB parent in Vero.