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. 2019 Sep 27;10(10):1393–1399. doi: 10.1021/acsmedchemlett.9b00310

Figure 3.

Figure 3

(A) In vitro cytotoxicities of immolative ADCs bearing peptides with different stereochemistries and of 1a against CA922 cells. (6a + Ab) indicates 6a plus 1000 equiv of anti-EGFR antibody. (B) Bystander killing (via assay 1) of immolative conjugates bearing peptides of different stereochemistries compared to 1a. RLU indicates relative luminescence units. (C) In vitro bystander killing activity (via assay 2) of immolative ADCs that have different n values and the disulfide-linked ADC 1b. The cell lines Jeg-3 cells (Ag+) and Nam\Luc (Ag−), which are Namalwa cells stably transfected with luciferase, were used.