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In vivo efficacy of maytansinoid ADCs against (A) homogeneously expressing mouse Hs746T xenografts (8 mice/group), (B) heterogeneously expressing HT-29 xenografts (6 mice/group, 5 mg/kg), (C) heterogeneously expressing HT-29 xenografts (6 mice/group, 2.5 mg/kg), and (D) heterogeneously expressing OV-90 xenografts (6 mice/group).
