Scheme 1. Synthesis of New Immolative Maytansinoid ADCs.
Reagents and conditions: (a) Zn(OTf)2, DIPEA; (b) Pb(OAc)4, AcOH; (c) HS-(CH2)n-COOH, TFA; (d) EDC, 14; (e) morpholine; (f) 22c, 23.
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