Table 2. Cell-Based Readthrough Activity of Derivative 13x to Several Nonsense Mutations.
| readthrough activitya |
|||
|---|---|---|---|
| compd | -TGA- | -TAG- | -TAA- |
| G418 (2) | 7.43 ± 0.22 | 7.86 ± 0.21 | 4.78 ± 0.14 |
| (+)-negamycin (4) | 1.47 ± 0.15 | 1.17 ± 0.31 | 1.13 ± 0.01 |
| TCP-126 (6) | 2.30 ± 0.05 | 1.30 ± 0.06 | 1.11 ± 0.05 |
| TCP-112 (7) | 3.80 ± 0.69 | 1.48 ± 0.07 | 1.20 ± 0.18 |
| TCP-1109 (13x) | 18.3 ± 0.26 | 4.39 ± 0.04 | 2.24 ± 0.41 |
a
Cell-based readthrough activity (ratio) relative to control (D-MEM) in COS-7 cells; compounds are evaluated at a concentration of 200 μM. Values are the mean ± SD (n = 3).