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. 2019 Oct 15;19:267. doi: 10.1186/s12906-019-2684-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The NF-κB and AMPK pathway were involved in anti-cachectic effects of CSO. a. Representative Western-blot images exhibit the expression of p-HSL (Ser660), HSL, p-AMPK (Thr172), AMPK inthe Ctrl group, CA group, and CA + Coix group. b.The band densityanalysis showed that p-HSL/HSL in adipose tissue differed significantly between three groups (4 samples per group). c.The quantification of band density showed that p-AMPK/AMPK differed significantly between three groups (4 samples per group). d.Representative Western-blot images exhibit the expression of phospho-p65 (Ser536), p65 and MuRF1 inthe Ctrl group, CA group, and CA + Coix group. e.The quantification of band density revealed the increased ratio of MuRF1 to GAPDH in muscle tissue induced by cachexia was decreased by CSO administration (4 samples per group). f. The band densityanalysis exhibited that phospho-p65/p65 was elevated in CA group compared to Ctrl group while CSO administration significantly decreased the ratio (4 samples per group). Values were expressed as mean ± SEM (*P<0.05, **P<0.01)