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. 2019 Oct 15;21:212. doi: 10.1186/s13075-019-1991-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Intracellular cytokine staining for IFN-γ, IL-4, and IL-17 after 4 h of in vitro stimulation. a IFN-γ-producing, b IL-4-producing, and c IL-17-producing Th cells in healthy controls (n = 14) and SSc patients (n = 22). d–f SSc patients were stratified for immunosuppressive therapy at the time of blood draw. Bars indicate SD. *p < 0.05, **p < 0.01