Table 3.

Summary of studies reporting clinical application of LITT in neurosurgery

Reviewed studies	Number of Cases	Indications for LITT	Outcome	Comments
Schwarzmaier et al. [32]	16; 2 sets of patient (10 + 6)	Recurrent glioblastoma	Median survival time: 5.2 for the first set, and 11.2 in the second set	Learning curve deemed responsible explaining different survival
Carpentier et al. [33]	4	Recurrent glioblastoma	Mean overall survival: 10.5 months	Three complications: transient dysphasia, seizure, and cerebrospinal fluid leak
Jethwa et al. [3]	20	Multiple primary brain tumors	No data about survival was provided	Four complications: arterial injury, refractory brain edema, pituitary injury, and misplacement of the laser probe
Banerjee et al. [2]		Recurrent grade III/IV glioblastoma	Median overall survival after LITT: 20.9 months, improved compared to other treatment modalities
Rao et al. [46]	14	Recurrent brain metastases after radiosurgery and/or whole-brain radiation	Median progression-free survival: 37 weeks, and overall survival: 57%
Carpentier et al. [44, 45]	2 studies: 2008: 4 2011:7	Recurrent or resistant cerebral metastases	2008: Not reported 2011: follow-up up to 30 month, median survival was 19.8 months
Bastos et al. [60]	61	Recurrent brain metastasis and radiation necrosis	Incomplete ablation and recurrent tumoral lesions were associated with a higher risk of treatment failure and were the major predicting factors for local recurrence Systemic therapy within 3 months after LITT was a protective factor against local recurrence
Kang et al. [64]	20	Epilepsy	LITT achieved a 53% rate of remission of disabling seizures
Waseem et al. [65]	7	Epilepsy	LITT achieved a 57% rate of remission of disabling seizures
Willie et al. [26]	13	Epilepsy	LITT achieved a 54% rate of remission of disabling seizures