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. 2019 Oct 15;12:102. doi: 10.1186/s13045-019-0796-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — APRIL and BAFF CSF levels in PCNSL during treatment. Patients with complete remission after methotrexate (MTX)-based polychemotherapy (n = 21) had significantly lower APRIL (a) and BAFF (b) CSF levels compared to patients with untreated newly diagnosed or relapsed PCNSL (n = 46). c–f Serial CSF analysis for APRIL (c, e) and BAFF (d, f) was performed before, during, and after methotrexate (MTX)-based polychemotherapy in 17 patients with newly diagnosed PCNSL (new DX). All of them experienced complete remission (CR) at the end of chemotherapy (CT). In 6 of these patients, relapse occurred during the observation period. c APRIL CSF levels decrease in 16/17 patients (94%) at CR, while in 1/17 patients (6%), APRIL levels remained stable (mean decrease: 63%). d BAFF CSF levels show variable courses during treatment and at CR (decrease in 10/17 patients (59%), increase in 6/17 (35%), stable in 1/17 (6%) with a mean decrease of 4%). e At relapse, APRIL CSF levels increase in 6/6 patients to a mean of 351% (range 123 to 633%. d BAFF CSF levels increase in 5/6 cases to a mean of 228% (range 85 to 311%)