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. 2019 Oct 15;19:953. doi: 10.1186/s12885-019-6206-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Effect of iASPP on autophagy. a Higher expression of LC3 was demonstrated in HM than normal placentas by immunohistochemistry (normal vs HM *; P = 0.043). Scale bar, 100 μm. b Choriocarcinoma cell lines, BeWo (2), JEG-3 (3) and JAR (4), expressed more LC3-II than normal trophoblast cell line HTR8/SVneo (1). The LC3 bands were quantified by using ImageJ. The LC3-II to LC3-I ratio on each cell line was analyzed and listed. c Knockdown of iASPP in choriocarcinoma cells decreased Atg5 and LC3-II expressions. d More GFP-LC3 puncta (arrows) were observed in choriocarcinoma cells treated with scramble control than those cells with iASPP knockdown. All the cells were treated with Bafilomycin A1 (20 nM) for 6 h before captured under microscope (200X)