Table 2.

Toxicokinetic parameters of BPA and BPS ($\text{mean}\pm \text{SD}$) estimated by noncompartmental analysis after BPA and BPS IV dosing.

Toxicokinetic parameter	BPA IV dosing ($n=15$)		BPS IV dosing ($n=16$)
	BPA	BPAG	BPS	BPSG
Cmax/dose ($\mathrm{\mu }\text{mol}/\mathrm{L}\text{\hspace{0.17em} per \hspace{0.17em}}\mathrm{\mu }\text{mol}/\mathrm{kg}$ BW)	$0.48\pm 0.43$	$1.80\pm 0.85$	$2.12\pm 1.82$*	$2.55\pm 0.58$
Tmax (h)	NA	$0.35\pm 0.34$	NA	$0.29\pm 0.19$
${\text{AUC}}_{0\text{- tlast}}/\text{dose}$ ($\mathrm{\mu }\text{mol}\times \mathrm{h}/\mathrm{L}\text{\hspace{0.17em} per \hspace{0.17em}}\mathrm{\mu }\text{mol}/\mathrm{kg}$)	$0.34\pm 0.14$	$2.04\pm 0.58$	$1.11\pm 0.30$*	$2.59\pm 0.77$
Cl ($\mathrm{L}/\text{kg}\times \mathrm{h}$)	$3.41\pm 1.23$	NA	$0.95\pm 0.24$*	NA
Cl_F ($\mathrm{L}/\text{kg}\times \mathrm{h}$)	NA	$0.51\pm 0.12$	NA	$0.41\pm 0.08$

Note: The toxicokinetic parameters after IV dosing were estimated from datasets obtained after a single IV administration of BPA at $21.9\mathrm{\mu }\mathrm{mol}/\mathrm{kg}$ (Exp. 1–2, $n=11$), a single IV administration of BPS at $20\mathrm{\mu }\mathrm{mol}/\mathrm{kg}$ (Exp. 3–4, $n=12$), and simultaneous IV administrations of BPA and BPS at the same dosage (Exp. 5, $n=4$). ${\text{AUC}}_{0\text{- tlast}}/\text{dose}$ Dose scaled area under the plasma concentration–time curve from dosing time to the time of the last measurable plasma concentration;BPA, Bisphenol A; BPAG, Bisphenol A glucuronide; BPS, Bisphenol S; BPSG, Bisphenol S glucuronide.; BW, Body weight; Cl, Clearance; Cl_F, Apparent clearance; Cmax/dose, Dose scaled maximal plasma concentration; IV, Intravenous; NA, not applicable; Tmax, Time of Cmax.

^*Significantly different from mean values obtained with BPA ($p<0.05$, ANOVA test).