Table 2.

Demographics of samples assessed with the human sperm capture panel.

Characteristic	Cohort
	Toronto	Montreal, pre-folic acid	Montreal, post-folic acid
	$n$, $\text{mean}\pm \text{SD}$, or range	$n$, $\text{mean}\pm \text{SD}$, or range	$n$, $\text{mean}\pm \text{SD}$, or range
Total number of participants ($n$)	21	12	12
Age
$\text{Mean}\pm \text{SD}$	$40.8\pm 8.6\mathrm{y}$	$39.3\pm 8.2\mathrm{y}$	$39.3\pm 8.2\mathrm{y}$
Range	28–61 y	26–53 y	26–53 y
Fertility statusa	Fertile	Infertile	Infertile
Sperm counts (million/mL)
$\text{Mean}\pm \text{SD}$	$73.2\pm 29.0$	$188.2\pm 174.5$	$203.0\pm 208.0$
Range	38.0–140.0	27.5–536.5	46.9–674.8
Percentage DFI (%)
$\text{Mean}\pm \text{SD}$	$15.0\pm 6.7$	$22.5\pm 9.6$	$18.2\pm 7.6$
Range	6.1–30.9	7.7–39.42	7.64–27.6
Smoking status ($n$)
Smokers	6	0	0
Nonsmokers	15	12	12
MTHFR genotype ($n$)
MTHFR CC	13	6	6
MTHFR TT	8	6	6
High-dose folic acid use [$5\mathrm{mg}/\mathrm{d}$ ($n$)]
Yes	0	0	12
No	21	12	0

Note: DFI, DNA fragmentation index; MTHFR, methylenetetrahydrofolate reductase; SD, standard deviation.

^aA fertile status was determined if participants were normospermic and presented to the clinic due to known female factor infertility (see “Methods” section).