Figure 7.

Influence of nanomolar DM on the gating kinetics of RyR1 channels. (A–C) Representative traces of RyR1 activity in single-channel level in the (A) absence, and (B) presence of $10\text{\hspace{0.17em} nM}$ and (C) $30\text{\hspace{0.17em} nM}$, respectively. (D) Analysis of the gating parameters of mean closed time (${\mathrm{\tau }}_{\mathrm{c}}$) (top), mean open time (${\mathrm{\tau }}_{\mathrm{o}}$) (middle), and open probability ($P_o$) (bottom). Each data point represents the $\text{mean}\pm \text{standard error of the mean \hspace{0.17em}}\left(\text{SEM}\right)$ from three independent channels. Statistical significance between groups was calculated by one-way analysis of variance (ANOVA) followed by post hoc Bonferroni comparison. Note: C, closed state of the channel; DM, deltamethrin; O, open state of the RyR1 channel; $P_o$, open probability; RyRs, ryanodine receptors; ${\mathrm{\tau }}_{\mathrm{o}}$, mean open time; ${\mathrm{\tau }}_{\mathrm{c}}$, mean closed time. **$p<0.01$, DM vs. control.