Table 3.

Effects of metformin and/or glyburide on prolactin serum level and other metabolic profile in patients with type 2 diabetes mellitus

Variables	Metformin	Glyburide	Combination	A	B	C	ANOVA
n	29	30	21
BMI (kg/m2)	30.10±3.81	31.45±3.66	30.40±2.98	NS	NS	NS	0.32
SBP (mmHg)	145.79±4.64	150.75±5.90	146.79±4.48	0.001*	NS	0.02×	0.001
DBP (mmHg)	88.95±7.67	95.11±5.22	90.39±5.29	0.0009*	NS	0.02×	0.0009
MAP (mmHg)	107.89±6.68	113.65±5.83	109.19±4.81	0.001*	NS	0.02×	0.001
FBG (mg/dl)	144.52±7.65	141.22±6.11	133.11±5.22	NS	0.0001*	0.0001*	0.0001
HbA1c	8.6±2.32	9.99±2.56	7.11±2.12	NS	NS	0.0002*	0.0003
FSI (mIU/l)	16.81±3.22	19.33±3.66	17.84±3.11	0.01×	NS	NS	0.01
HOMA-IR	2.39±1.01	2.72±1.05	2.49±1.01	NS	NS	NS	NS
HOMA-β%	66.4±4.95	76.4±7.95	80.3±5.29	0.0001*	0.0001*	NS	0.0001
TG (mg/dL)	188.24±12.5	201.63±13.85	182.71±12.63	0.0005*	NS	0.0001*	0.00001
TC (mg/dL)	191.61±11.8	207.12±13.92	199.73±13.43	0.0001*	NS	NS	0.0001
LDL (mg/dL)	110.14±9.71	126.83±10.49	114.44±9.47	0.0001*	NS	0.0001*	0.0001
HDL (mg/dL)	43.82±7.83	39.96±5.53	48.74±4.12	0.04×	0.01×	0.0001*	0.00001
VLDL (mg/dL)	37.64±5.56	40.32±6.39	36.54±3.47	NS	NS	0.04×	0.03
AI	0.27±0.01	0.34±0.02	0.21±0.01	0.0001*	0.0001*	NS	0.0001
CRP (mg/L)	2.61±1.82	3.96±1.94	2.33±0.41	0.006*	NS	0.002*	0.0009
Prolactin (ng/ml)	32.88±5.85	38.71±6.79	35.89±6.51	0.002*	NS	NS	0.003

*P<0.01, ^×P<0.05. BMI: Body mass index, SBP: Systolic blood pressure, DBP: Diastolic blood pressure, MAP: Mean arterial pressure, FSI: Fasting serum insulin, FBG: Fasting blood glucose, HbA1c: Glycated hemoglobin, HOMA-IR: Homeostatic model assessment-insulin resistance, β%: β-cell function, S%: Insulin sensitivity, TG: Triglyceride, TC: Total cholesterol, LDL: Low-density lipoprotein, HDL: High-density lipoprotein, VLDL: Very low-density lipoprotein, AI: Atherogenic index, CRP: C-reactive protein, NS: Not significant, A: Metformin versus glyburide, B: Metformin versus combination, C: Glyburide versus combination, ANOVA: Analysis of variance