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. 2019 Oct 7;374(1786):20190088. doi: 10.1098/rstb.2019.0088

Table 3.

Summary of the protein domains acquired before and at the origins of animals, which are maintained by all 21 metazoan extant species used in this analysis.

origin protein domains retained protein domain information
Opisthokonta transcription factors and DNA binding domains
T-box transcription factor involved in animal development
BTD nuclear effector of Notch signalling
LAG1-DNAbind related to BTD, nuclear effector of Notch signalling
NUDE_C involved in chromosome migration
PAS_11 interacts with STAT6 transcription factor
signalling and GTPase interactors
Arfaptin involved in the vesicle budding at Golgi apparatus
GIT_SHD signalling integrators with GTPase activity
translational regulator
RAC_head involved in ribosomal binding
unknown function
Calpolin
HS1_rep
DUF3518
DUF3585
Holozoa signalling binding-related domains
GKAP interacts with guanylate kinase-like domain
PID phosphotyrosine interacting domain
LLGL known to be present in syntaxin-binding proteins
nuclear membrane protein
LEM found in inner nuclear membranes
transcription factor
Runt transcription factor related to animal development
unknown function
DUF1908
Filozoa signalling and adhesion
Integrin_alpha2 extracellular domain of integrins
ubiquitination
Beta-TrCP_D D domain of beta-TrCP that acts as ubiquitin ligase
Choanozoa transcription factors
MH1 DNA binding domain of Smad TF
MH2 domain that interacts with Smad TF regulators
Pou domain related with Homeobox superfamily
extracellular matrix protein domains
Laminin_N N terminal domain of laminins, extracellular proteins related to cell adhesion
P4Ha_N domain from prolyl 4-hydroxylase that is important in the post-translational modification of collagen
TSP_C C terminal domain of Thrombospondin, an adhesive glycoprotein that mediates cell-to-cell and cell-to-ECM interactions
protein–protein interactions
PET suggested to be involved in protein–protein interactions
lysosomal protein
Lamp integral membrane proteins of the lysosome with unclear functions
Metazoa signalling
wnt Wnt signal transduction pathways
TGF_beta transforming growth factor beta, regulatory peptides that generate intracellular signals
PP2C_C C terminal of serine/threonine phosphatase, the domain may provide specificity to the reaction
transcription factors
Ets transcription factor involved in multiple processes, cell differentiation, migration, etc.
Hormone_receptor ligand-binding domain of nuclear receptors that sense steroid and thyroid hormones
extracellular matrix protease
ADAM_CR membrane-anchored protease that modifies the ECM
protein–protein interaction
Death interaction protein module. Related with death effector domain and caspase recruitment domain