Opisthokonta |
transcription factors and DNA binding domains |
|
T-box
|
transcription factor involved in animal development |
BTD
|
nuclear effector of Notch signalling |
LAG1-DNAbind
|
related to BTD, nuclear effector of Notch signalling |
NUDE_C
|
involved in chromosome migration |
PAS_11
|
interacts with STAT6 transcription factor |
signalling and GTPase interactors |
|
Arfaptin
|
involved in the vesicle budding at Golgi apparatus |
GIT_SHD
|
signalling integrators with GTPase activity |
translational regulator |
|
RAC_head
|
involved in ribosomal binding |
unknown function |
|
Calpolin
|
|
HS1_rep
|
|
DUF3518
|
|
DUF3585
|
|
Holozoa |
signalling binding-related domains |
|
GKAP
|
interacts with guanylate kinase-like domain |
PID
|
phosphotyrosine interacting domain |
LLGL
|
known to be present in syntaxin-binding proteins |
nuclear membrane protein |
|
LEM
|
found in inner nuclear membranes |
transcription factor |
|
Runt
|
transcription factor related to animal development |
unknown function |
|
DUF1908
|
|
Filozoa |
signalling and adhesion |
|
Integrin_alpha2
|
extracellular domain of integrins |
ubiquitination |
|
Beta-TrCP_D
|
D domain of beta-TrCP that acts as ubiquitin ligase |
Choanozoa |
transcription factors |
|
MH1
|
DNA binding domain of Smad TF |
MH2
|
domain that interacts with Smad TF regulators |
Pou
|
domain related with Homeobox superfamily |
extracellular matrix protein domains |
|
Laminin_N
|
N terminal domain of laminins, extracellular proteins related to cell adhesion |
P4Ha_N
|
domain from prolyl 4-hydroxylase that is important in the post-translational modification of collagen |
TSP_C
|
C terminal domain of Thrombospondin, an adhesive glycoprotein that mediates cell-to-cell and cell-to-ECM interactions |
protein–protein interactions |
|
PET
|
suggested to be involved in protein–protein interactions |
lysosomal protein |
|
Lamp
|
integral membrane proteins of the lysosome with unclear functions |
Metazoa |
signalling |
|
wnt
|
Wnt signal transduction pathways |
TGF_beta
|
transforming growth factor beta, regulatory peptides that generate intracellular signals |
PP2C_C
|
C terminal of serine/threonine phosphatase, the domain may provide specificity to the reaction |
transcription factors |
|
Ets
|
transcription factor involved in multiple processes, cell differentiation, migration, etc. |
Hormone_receptor
|
ligand-binding domain of nuclear receptors that sense steroid and thyroid hormones |
extracellular matrix protease |
|
ADAM_CR
|
membrane-anchored protease that modifies the ECM |
protein–protein interaction |
|
Death
|
interaction protein module. Related with death effector domain and caspase recruitment domain |