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. 2019 Aug 22;8(13):6064–6081. doi: 10.1002/cam4.2494

Figure 8.

Figure 8

PART1 functioned as ceRNA of miR‐635 to activate JAK‐STAT signaling pathway. A, Detection of PART1 on activity of wild‐type or mutant 3′UTR of JAK1 and JAK3 by dual‐luciferase reporter assay. ***P < .001. B, Detection of PART1 on expression of JAK1, JAK3, p‐JAK1, p‐JAK3, STAT3, p‐STAT3, TIMP‐1, and Pim‐1 by western blot. **, ***P < .01, P < .001. C, Detection of PART1 and miR‐635 mimics on expression of JAK1, JAK3, p‐JAK1, p‐JAK3, STAT3, p‐STAT3, TIMP‐1, and Pim‐1 by western blot. **, ***P < .01, P < .001. ceRNA, competing endogenous RNA; JAK, Janus kinase; PART1, prostate androgen‐regulated transcript 1; Pim‐1, proto‐oncogene serine/threonine‐protein kinase; STAT, signal transducer and activator of transcription protein; TIMP‐1, tissue inhibitor of metalloproteinases