Skip to main content
. 1998 Jul 1;18(13):4861–4869. doi: 10.1523/JNEUROSCI.18-13-04861.1998

Fig. 2.

Fig. 2.

Effect of METH on tryptophan hydroxylase activity. 5-HTP accumulation in the striatum and hippocampus of wild-type and DAT −/− mice 60 min after METH treatment (single injection, 30 mg/kg, s.c.) was used as an indicator of tryptophan hydroxylase activity, as described under Materials and Methods. Concentrations of 5-HTP in saline-treated controls were 0.305 ± 0.043 ng/mg tissue in striatum (n = 5) and 0.697 ± 0.026 ng/mg tissue in hippocampus (n = 8). Values represent the mean ± SEM of five to eight animals per group. **p < 0.01 versus controls and *p < 0.05 versus controls.