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Effect of METH (single injection, 30 mg/kg, s.c.) on extracellular levels of striatal DA (A) and DOPAC (B). Microdialysis was used to measure extracellular monoamine levels in freely moving mice, as described under Materials and Methods. Basal concentrations of DOPAC in dialysates were 11.8 ± 2.3 pmol/20 μl in wild-type and 6.8 ±.2.4 pmol/20 μl in DAT −/− mice. Values represent the mean ± SEM of five to seven independent experiments.
