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Profiles of novel wheel-running-induced alterations in 5-HT release from the SCN region during midday (ZT 4–7) and during the late dark phase (ZT 19–22). Solid bardenotes the 3 hr period of confinement in the wheel. *p < 0.05 relative to prerunning baseline. Data from all animals in each group are included irrespective of running intensity. Inset, Bars represent total number of revolutions over the 3 hr wheel-running period for both groups. *p < 0.05 between groups.
