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Endogenous cAMP-dependent activity plays a key role in the disappearance of the BDNF collapsing effect on neurons in 24 hr cultures. A, BDNF was apparently ineffective in inducing growth cone collapse in 24 hr cultures. However, when endogenous cAMP-dependent activity was inhibited by 100 μm (Rp)-cAMP, the collapsing effect of BDNF was clearly observed (B). *Significantly different from the data inA at corresponding times (p< 0.001, Mann–Whitney test).
