Table 1.

ChAT levels in sham versus¹⁹²IgG-saporin-lesioned rats

Brain region	ChAT Level (mean ± SEM)
	Experiment 1		Experiment 2
	Sham (n = 10)	Lesion (n = 9)	Sham (n = 11)	Lesion (n = 10)
Hippocampus	37.8  ± 2.0	12.8  ± 3.6***	48.3  ± 4.1	15.2  ± 4.5***
Anterior cortex	35.2  ± 1.4	15.3  ± 3.1***	39.9  ± 2.7	19.1  ± 3.8**
Posterior cortex	35.3  ± 1.3	20.1  ± 4.6*	39.6  ± 4.0	23.6  ± 3.0*
Olfactory bulbs			56.0  ± 9.8	20.9  ± 3.5*
Caudate			76.2  ± 7.6	68.0  ± 10.1

ChAT activity is presented as nanomoles of ACh formed per hour per milligram of protein. Significant reductions were detected in hippocampus, anterior cortex, posterior cortex, and olfactory bulbs.

*–***Significantly different compared with sham controls. *p < 0.01; **p < 0.001; ***p < 0.0001.