Table 2.
Monoamines and metabolites in thalamus (Thal), hypothalamus (Hypo), brainstem (BS), and cerebellum (CB) of control and transgenic mice
| Compound | Thal | Hypo | BS | CB | |
|---|---|---|---|---|---|
| NA | Control | 3.74 ± 0.80 | 13.03 ± 1.35 | 5.51 ± 1.08 | 1.38 ± 0.18 |
| Transgenic | 3.56 ± 0.70 | 8.15 ± 1.76 | 4.69 ± 0.77 | 1.10 ± 0.45 | |
| DA | Control | 2.30 ± 0.74 | 2.13 ± 0.45 | 1.05 ± 0.18 | n.d. |
| Transgenic | 1.73 ± 0.61 | 0.99 ± 0.11* | 0.96 ± 0.21 | n.d. | |
| DOPAC | Control | 2.23 ± 0.54 | 6.72 ± 0.53 | 0.99 ± 0.16 | n.d. |
| Transgenic | 2.89 ± 0.75 | 6.39 ± 1.64 | 0.86 ± 0.17 | n.d. | |
| HVA | Control | 2.50 ± 0.75 | 2.82 ± 1.11 | 1.01 ± 0.18 | n.d. |
| Transgenic | 3.40 ± 2.51 | 3.23 ± 0.72 | 1.23 ± 0.27 | n.d. | |
| 5-HT | Control | 5.08 ± 0.63 | 6.61 ± 1.33 | 7.97 ± 1.09 | 1.83 ± 0.43 |
| Transgenic | 5.85 ± 1.03 | 7.76 ± 1.98 | 8.42 ± 0.97 | 1.89 ± 0.55 | |
| 5-HIAA | Control | 7.61 ± 0.42 | 8.12 ± 1.66 | 9.48 ± 1.20 | 1.59 ± 0.28 |
| Transgenic | 6.99 ± 1.25 | 7.37 ± 1.41 | 8.64 ± 1.31 | 1.95 ± 0.27 |
The values are the means ± SEM (n = 6) in nanograms per milligram of protein. The compounds are NA, noradrenaline; DA, dopamine; DOPAC, 3,4-dihydroxyphenylalanine; HVA, homovanillic acid; 5-HT, serotonin; and 5-HIAA, 5-hydroxyindole-3-acetic acid. n.d., Not determined. Statistical comparisons were made by Student’s t test.
*p < 0.05.