Fig. 6.

Effects of TEA, Ibtx, and 4-AP on outward currents in enzymatically dissociated hair cells. Essentially all of the outward current recorded in normal extracellular solution (control) was eliminated by 6 mm TEA (A) or 2 μm Ibtx (B). Application of 1 mm 4-AP (C) had no effect. The panels to the right show the I–Vrelationship for each cell before (□) and during (•) drug application. Currents for I–V plots were calculated at the end of each 50 msec step. All recordings were made using a whole-cell configuration and from a holding potential of −70 mV. For each family of traces, the largest amplitude voltage step (corrected for series resistance errors) is indicated next to the step protocol. For clarity, some of the data traces used to construct theI–V plots are not shown.