Fig. 7.

Effects of TEA, Ibtx, and 4-AP on outward currents from hair cells in the semi-intact epithelial preparation. Application of 6 mm TEA (A) or 1 μmIbtx (B) blocked a fast component of the outward current, leaving a more slowly activating component. 1 mm4-AP (C) blocked a slow component of the outward current, leaving a rapidly activating outward current that partially inactivated. Nearly all outward current was eliminated by applying both 1 mm 4-AP and 6 mm TEA (D). The panels to the right show the I–V relationship for each cell before (□) and during (•) drug application (see Fig. 6 legend). The recordings in B were made using perforated patch; the others (A, C, D) were made in the whole-cell configuration.