Fig. 8.

TEA-, 4-AP-, and Ibtx-sensitive currents (dark traces) in hair cells in the semi-intact epithelial preparation obtained by subtracting the currents after drug application (smaller-amplitude light traces) from the currents in control conditions (larger-amplitude light traces). A, Current blocked by 6 mmTEA activated rapidly and partially inactivated. B, One micromolar Ibtx blocked a similar component of the current.C, One millimolar 4-AP blocked a slowly activating current. Because of series resistance errors in the step potential it was necessary to estimate the current at −20 mV by linear interpolation of currents from adjacent voltage steps. These are the same cells as in Figure 8A–C.