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Potentiation of NMDA-induced current by intracellular acidification. A, The soma of an isolated neuron was whole-cell voltage-clamped at −60 mV. Local perfusion with NMDA from a glass micropipette (NMDA) as indicated in the right panel induced an inward current. NMDA-induced current was enhanced by intracellular acidification with either acetate (A) or propionate (B) but not affected by cytosolic alkalinization (C). Scale bar, 10 μm. R, Patch pipette.
