Fig. 1.
A–D, Startle responses without prepulses (A, B) and prepulse inhibition (PPI) of the startle reflex (C, D) in drug-naive mice with altered α2C-AR expression. Data are presented as mean ± SEM (n = 42–49). The mean startle response amplitude of mice with targeted disruption of the α2C-AR (α2C-KO) (hatched bars) were higher than in their respective wild-type control group (open bars). In addition, α2C-KO mice had diminished PPI, and mice overexpressing the α2C-ARs (α2C-OE mice) (closed bars) had increased PPI compared with respective wild-type controls (Mann–Whitney U test). *p < 0.05; **p < 0.01.