Fig. 5.
A–D, Prepulse inhibition (PPI) of the startle reflex in drug-naive mice with altered α2C-AR expression after 7–8 weeks of isolation (n = 14–18). Compared with group-housed mice (Fig.1A–D), isolation had no clear effect in mice with targeted disruption of the α2C-AR gene (α2C-KO) (hatched bars) or in their controls (α2C-KO-wt) (open bars), but it reduced startle responsiveness in mice overexpressing the α2C-AR (α2C-OE) (closed bars) and increased the PPI in both α2C-OE mice and in their wild-type controls (α2C-OE-wt) (open bars).